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Loic autret
Loic autret















#Loic autret trial#

The primary objective of this study is to assess whether short-term (48 h) tocolysis reduces perinatal mortality/morbidity in PPROM at 22 to 33 completed weeks of gestation.Ī randomized, double-blind, placebo-controlled, superiority trial will be performed in 29 French maternity units. In theory, reducing uterine contractility could delay delivery and reduce the risks of prematurity and its adverse short- and long-term consequences, but it might also prolong fetal exposure to inflammation, infection, and acute obstetric complications, potentially associated with neonatal death or long-term sequelae. Up-to-date evidence about the risks and benefits of administering tocolysis after PPROM, however, is lacking. International guidelines recommend expectant management, along with antenatal steroids before 34 weeks and antibiotics.

loic autret

Preterm prelabor rupture of membranes (PPROM) before 34 weeks of gestation complicates 1% of pregnancies and accounts for one-third of preterm births. Gilles Kayem, Elsa Lorthe, Pierre-Yves Ancel, Hendy Abdoul, Nelly Briand, Blandine Lehmann, Clémence Cabanne, Stéphane Marret, Laurence Foix l'Hélias, François Goffinet, Thomas Schmitz, Caroline Charlier, Fanny Autret, Elie Azria, Jadot Balitalike, Kareen Billiemaz, Caroline Bohec, Pascal Bolot, Marie Bornes, Hanane Bouchghoul, Malek Bourennane, Florence Bretelle, Lionel Carbillon, Christine Castel, Céline Chauleur, Romain Corroenne, Karen Coste, Valérie Datin-Dorrière, Raoul Desbriere, Luc Desfrere, Michel Dreyfus, Marc Dommergues, Xavier Durrmeyer, Géraldine Favrais, Cyril Flamant, Denis Gallot, Julie Gries, Bassam Haddad, Laure Julé, Cécile Laffaille, Jacques Lepercq, Emmanuelle Letamendia, Fanny de Marcillac, Caroline Miler, Olivier Morel, Karine Norbert, Franck Perrotin, Christophe Poncelet, Laurent Renesme, Claire Roumegoux, Patrick Rozenberg, Mireille Ruiz, Loïc Sentilhes, Jeanne Sibiude, Damien Subtil, Nadia Tillouche, Héloïse Torchin, Barthélémy Tosello, Eric Verspyck, Alexandre Vivanti, Norbert Winer















Loic autret